We are curious by nature. We love science and have the sense of wonder that is required to succeed in an uncharted area such as aging. We’re excited and humbled by the opportunity.
Aging is like a snowball exponentially growing and gaining momentum as it rolls down a hill. Can we delay its start or reduce its speed ? We believe that the answer to this shall be found in systems biology.
Our mission is said simply, yet it is quite ambitious. We want to better understand the biology that controls aging and lifespan…and we want to use the knowledge we gain to discover and develop interventions that enable people to live longer and healthier lives.
We are not a traditional biotechnology company, nor are we an academic institution. We look to combine the best parts of both without the constraints of either.
We are asking difficult questions about how we age and the diseases associated with the aging process. To find answers requires a long-term perspective, a relentless focus on understanding the basic biology of aging, utilizing or inventing state-of-the-art technology, enlisting advanced computing capabilities and nurturing a culture and values that guide the big and small decisions we make every day.
Our research has been across
Cell Reprogramming - In essence, reprograming works by adding proteins to a cell, which then instruct the cell to revert to a state where it can generate new, young cells that form the basis of the human body.
Transdifferentiation - Transdifferentiation reprograms the specialized cells to become new cells, allowing to regrow themselves in an entirely different body plan to the old cells they had recently been. They can then mature again from there as normal, producing new, genetically identical cells.
Telomerase and Telomere Length - Every time cells divide, their telomeres shorten, which eventually prompts them to stop dividing and die. Telomerase prevents this decline in some kinds of cells, including stem cells, by lengthening telomeres, and the hope was that activating the enzyme could slow cellular ageing.
Different by design
Like much of the work we do in research, our development approach is different by design. Our efforts focus on identifying new targets — that are not currently being pursued by many others — based on our evolving understanding of the biology of aging and age-related diseases.
We’re translating that research into first-in-class compounds to target diseases commonly linked with aging with the goal of not only improving life span but also health span.
We believe that focusing on new areas of biology and making big leaps in science and then translating these efforts into drug candidates for potential clinical development will lead to patient benefit.